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?з???̹????????˥?ߺϲ??????ܲ?ȫ???о?_qy国际官网老虎机 ?з???̹????????˥?ߺϲ??????ܲ?ȫ???о?_qy国际官网老虎机

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[1]Ҷ͢??,?? ??,?? ??,??.?з???̹????????˥?ߺϲ??????ܲ?ȫ???о?[J].ҽѧ??Ϣ,2020,(15):69-72.[doi:10.3969/j.issn.1006-1959.2020.15.022]
??YE Ting-qiao,ZHAO Liang,YU Hui,et al.Tolvaptan in the Treatment of Heart Failure with Renal Insufficiency[J].Medical Information,2020,(15):69-72.[doi:10.3969/j.issn.1006-1959.2020.15.022]
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ҽѧ??Ϣ[ISSN:1006-1959/CN:61-1278/R]

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2020??15??
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69-72
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2020-08-01

??????Ϣ/Info

Title:
Tolvaptan in the Treatment of Heart Failure with Renal Insufficiency
???±??:
1006-1959??2020??15-0069-04
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Ҷ͢??1?? ??1?? ??1?? ٻ1֣ ??2
1.??????????ҽԺ??Ѫ???ڿƣ??Ĵ? ???? 621000??2.???????ϴ???????ҽԺ??Ѫ???ڿƣ????? 408400
Author(s):
YE Ting-qiao1ZHAO Liang1YU Hui1GONG Qian1ZHENG Xi2
1.Department of Cardiovascular Medicine,Mianyang Central Hospital,Mianyang 621000,Sichuan,China;2.Department of Cardiovascular Medicine,Nanchuan District People??s Hospital,Chongqing 408400,China
?ؼ???:
?з???̹????˥???????ܲ?ȫ?????
Keywords:
TolvaptanHeart failureRenal insufficiencyDiuretics
?????:
R541.6??R692
DOI:
10.3969/j.issn.1006-1959.2020.15.022
???ױ?־??:
A
ժҪ:
Ŀ?? ?۲??з???̹????????˥?ߺϲ??????ܲ?ȫ???ٴ???Ч????ȫ?ԡ????? ѡȡ??????????ҽԺ??Ѫ???ڿ?2017??1??~2019??1?????ε?????˥?ߺϲ??????ܲ?ȫ??110?????ߣ??????Ϊ????????з???̹?飬??55????????????賣???֢???ƣ??з???̹???ڶ????????֮?ϼ????з???̹???Ƚ????????ƺ?1?ܺ?1???µ??ٴ???Ч????????Ӧ???????????? ?з???̹?????ƺ?1?ܺ?1???µ?????Ч?ʡ?24 h??????Ѫ???ơ?6 min???о???????ڶ????飬??????ͳ??ѧ???壨P??0.05?????з???̹?????ƺ?1?ܺ?1???µ?proBNPˮƽ?????ؾ????ڶ????飬??????ͳ??ѧ???壨P??0.05?????з???̹?????ƺ?1?µ?Ѫ????????????Ӧ????סԺ?ʺ???˥????ʱ??????ڶ????飬??????ͳ??ѧ???壨P??0.05???????? ?з???̹?????Ը???????˥?ߺϲ??????ܲ?ȫ???ߵ??ٴ?֢״????????˥????ʱ?䡢?ӻ??????ܶ񻯣?ͬʱ??????Ӧ?????ʵ͡?
Abstract:
Objective To observe the clinical efficacy and safety of tolvaptan in the treatment of heart failure with renal insufficiency.Methods A total of 110 patients with heart failure and renal insufficiency who were admitted to the Department of Cardiovascular Medicine of Mianyang Central Hospital from January 2017 to January 2019 were selected and randomly divided into control group and tolvaptan group, with 55 cases in each group. The control group was given conventional symptomatic treatment, and the tolvaptan group was given tolvaptan on the basis of the control group. The clinical efficacy and adverse reactions of the two groups were compared one week and one month after treatment.Results The total effective rate, 24-hour urine output, serum sodium, and 6-min walking distance in the tolvaptan group at 1 week and 1 month after treatment were higher than those in the control group,the difference was statistically significant (P??0.05); tolvaptan the proBNP level and body weight of the tan group were lower than those of the control group one week and one month after treatment,the difference was statistically significant (P??0.05); the blood creatinine, adverse reactions, and rehospitalization rate of the tolvaptan group one month after treatment time to correct heart failure was lower than that of the control group,the difference was statistically significant (P??0.05).Conclusion Tolvaptan can significantly improve the clinical symptoms of patients with heart failure and renal insufficiency, shorten the correction time of heart failure, delay the deterioration of renal function, and reduce the incidence of adverse reactions.

?ο?????/References:

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