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CHF????Ѫ???״?ټ????쳣??С???????״?????????Ƶ?Ч??_qy国际官网老虎机 CHF????Ѫ???״?ټ????쳣??С???????״?????????Ƶ?Ч??_qy国际官网老虎机

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[1]??ε??,?Ž?ΰ.CHF????Ѫ???״?ټ????쳣??С???????״?????????Ƶ?Ч??[J].ҽѧ??Ϣ,2020,(15):73.[doi:10.3969/j.issn.1006-1959.2020.15.023]
??DU Wei-bei,ZHANG Jian-wei.Serum Thyroid Hormone Abnormalities in CHF Patients and the Effect of Low-dose Levothyroxine Sodium Therapy[J].Medical Information,2020,(15):73.[doi:10.3969/j.issn.1006-1959.2020.15.023]
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ҽѧ??Ϣ[ISSN:1006-1959/CN:61-1278/R]

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2020??15??
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73
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2020-08-01

??????Ϣ/Info

Title:
Serum Thyroid Hormone Abnormalities in CHF Patients and the Effect of Low-dose Levothyroxine Sodium Therapy
???±??:
1006-1959??2020??15-0073-04
????:
??ε???Ž?ΰ
?????е?һ????ҽԺ?ڷ??ڿƣ????? ???? 650011
Author(s):
DU Wei-beiZHANG Jian-wei
Department of Endocrinology,Kunming First People??s Hospital,Kunming 650011,Yunnan,China
?ؼ???:
????????˥????״?ټ??????״???????Ĺ?????֢????
Keywords:
Chronic heart failureThyroid hormoneLevothyroxine sodiumHeart function Inflammatory factor
?????:
R541.6
DOI:
10.3969/j.issn.1006-1959.2020.15.023
???ױ?־??:
A
ժҪ:
Ŀ?? ̽??????????˥?ߣ?CHF??????Ѫ???״?ټ???ˮƽ??С???????״?????????Ƶ?Ч???????? ѡȡ2016??4??~2018??4??????Ժ???Ƶ?CHF????110????ΪCHF?飬ͬʱѡȡ????־Ը??100????Ϊ?????飻ͬʱ???????Ʒ?????CHF???Ϊ?۲??飨52?????Ͷ????飨58??????????????賣?????ƣ??۲????ڶ?????Ļ???????С???????״?????????ơ??Ƚϸ???Ѫ???״?ټ???ˮƽ???ȽϹ۲???Ͷ?????????ǰ???״?ټ???ˮƽ???Ĺ???ָ?ꡢhs-CRP??IL-6ˮƽ????????Ӧ?ȡ????CHF??T3??FT3ˮƽ?????????飬??????ͳ??ѧ???壨P??0.05????CHF?????????T4??FT4??FSHˮƽ?Ƚϣ???????ͳ??ѧ???壨P??0.05???????ƺ󣬹۲???Ͷ?????T4??FT4??FSHˮƽ?Ƚϣ???????ͳ??ѧ???壨P??0.05?????۲???Ͷ?????T3??FT3????????ǰ???ߣ??ҹ۲?????ڶ????飬??????ͳ??ѧ???壨P??0.05?????۲???Ͷ?????LVEF??CI??SV????????ǰ???ƣ??ҹ۲???LVEF??CI??SV???ڶ????飬??????ͳ??ѧ???壨P??0.05?????۲???Ͷ?????hs-CRP??IL-6????????ǰ???ƣ??ҹ۲???hs-CRP??IL-6???ڶ????飬??????ͳ??ѧ???壨P??0.05?????۲???Ͷ?????δ?????????ز???֢?????????? CHF????Ѫ??T3??FT3ˮƽ??????????Ⱥ??????С???????״???????ܸ??ƻ??߼?״?ټ???ˮƽ?????๦?ܣ???????֢??Ӧ????ȫ?????ã?ֵ???ٴ?Ӧ?á?
Abstract:
Objective To investigate the serum thyroid hormone level and the effect of low-dose levothyroxine sodium in patients with chronic heart failure (CHF). Methods 110 CHF patients treated in our hospital from April 2016 to April 2018 were selected as the CHF group, and 100 healthy volunteers were selected as the normal group; at the same time, the CHF group was divided into the observation group (52 cases) according to the treatment plan and the control group (58 cases), the control group was given conventional treatment, and the observation group was given low-dose levothyroxine sodium treatment on the basis of the control group. The serum thyroid hormone levels of each group were compared, and the thyroid hormone levels, heart function indexes, hs-CRP and IL-6 levels and adverse reactions were compared between the observation group and the control group before and after treatment. Results The levels of T3 and FT3 in the CHF group were lower than those in the normal group,the difference was statistically significant (P<0.05); there was no significant difference in the levels of T4, FT4, and FSH between the CHF group and the normal group (P>0.05). After treatment, there was no statistically significant difference in the levels of T4, FT4 and FSH between the observation group and the control group (P>0.05); T3 and FT3 in the observation group and the control group were higher than before treatment, and the observation group was higher than the control group,the difference was statistically significant (P<0.05); the LVEF, CI and SV of the observation group and the control group were improved compared with before treatment, and the LVEF, CI and SV of the observation group were higher than the control group, the difference was statistically significant (P<0.05) ; The hs-CRP and IL-6 of the observation group and the control group were improved compared with before treatment, and the hs-CRP and IL-6 of the observation group were lower than the control group, the difference was statistically significant (P<0.05). No serious complications were found in the observation group and the control group. Conclusion The serum T3 and FT3 levels of CHF patients are lower than those of the normal population. Low-dose levothyroxine sodium can improve patients?? thyroid hormone levels and cardiac function, inhibit inflammation, and has good safety. It is worthy of clinical application.

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