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[1]??????,ʯ????.??ɳ̹????ǰ?еض???????????С?????׵?Ч??[J].ҽѧ??Ϣ,2020,(15):151-153.[doi:10.3969/j.issn.1006-1959.2020.15.048]
??CHEN Yu-yang,SHI Ai-jie.The Effect of Valsartan Combined with Alprostadil on Chronic Glomerulonephritis[J].Medical Information,2020,(15):151-153.[doi:10.3969/j.issn.1006-1959.2020.15.048]
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ҽѧ??Ϣ[ISSN:1006-1959/CN:61-1278/R]

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2020??15??
ҳ??:
151-153
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ҩ?????ٴ?
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2020-08-01

??????Ϣ/Info

Title:
The Effect of Valsartan Combined with Alprostadil on Chronic Glomerulonephritis
???±??:
1006-1959??2020??15-0151-03
????:
??????ʯ????
????ҽԺ???ڿƣ???? 300300
Author(s):
CHEN Yu-yangSHI Ai-jie
Department of Nephrology,Dongli Hospital,Tianjin 300300,China
?ؼ???:
??С??????ǰ?еض???ɳ̹????????????״̬
Keywords:
GlomerulonephritisAlprostadilValsartanQuality of lifeMental state
?????:
R692.31
DOI:
10.3969/j.issn.1006-1959.2020.15.048
???ױ?־??:
A
ժҪ:
Ŀ?? ̽????ɳ̹??ɢƬ????ǰ?еض?ע??Һ????????С???????????е?Ӧ??Ч???????? ѡȡ2018??4??~2020??4????Ժ???ε???????С?????׻???72????Ϊ?о??????????Ϊ?۲??鼰?????飬??36??????????Ӧ????ɳ̹??ɢƬ???ƣ??۲????ڴ˻????ϼ???ǰ?еض?ע??Һ???ƣ??Ƚ??????ٴ???Ч????????Ӧ?????ʡ?Ѫѹ?仯???????????ָ?ꡢ??????????????״̬???֡???? ?۲???????????Ч??Ϊ94.44%?????ڶ??????75.00%????????ͳ??ѧ???壨P??0.05?????۲??鲻????Ӧ??????Ϊ2.78%?????ڶ??????19.44%????????ͳ??ѧ???壨P??0.05?????۲???Ѫѹ??????????ڶ????飬??????ͳ??ѧ???壨P??0.05?????۲???Scr??BUN??24h Upro?????ϸ??ˮƽ???ƾ????ڶ????飬??????ͳ??ѧ???壨P??0.05?????۲?????ᡢ???塢?????????????ۺ????־????ڶ????飬??????ͳ??ѧ???壨P??0.05?????۲????SAS??SDS???־????ڶ????飬??????ͳ??ѧ???壨P??0.05???????? ??ɳ̹??ɢƬ????ǰ?еض?ע??Һ??????????С???????ٴ???Чȷ?У??ɽ??Ͳ?????Ӧ?????ƻ????????ܣ???Ч????Ѫѹ?????????ߵ?????????????????????״̬??ֵ???ٴ?Ӧ?á?
Abstract:
Objective To explore the effect of valsartan dispersible tablets combined with alprostadil injection in the treatment of chronic glomerulonephritis.Methods A total of 72 patients with chronic glomerulonephritis admitted to our hospital from April 2018 to April 2020 were selected as the research objects, and they were randomly divided into observation group and control group, with 36 cases in each group. The control group was treated with valsartan dispersible tablets, and the observation group was treated with alprostadil injection on this basis; the clinical efficacy, incidence of adverse reactions, blood pressure changes, renal function indexes, quality of life and mental state scores were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.44%, which was higher than 75.00% in the control group,the difference was statistically significant (P<0.05); the adverse reaction rate in the observation group was 2.78%, which was lower than 19.44% in the control group,the difference was statistically significant(P??0.05); the control of blood pressure in the observation group was better than that of the control group,the difference was statistically significant (P??0.05); the improvement in the levels of Scr, BUN, 24h Upro, and urinary red blood cells in the observation group was better than that of the control group, the difference was statistically significant (P??0.05); the social, physical, environmental, psychological and comprehensive scores of the observation group were higher than those of the control group,the difference was statistically significant (P??0.05); the SAS and SDS scores of the observation group were all lower In the control group, the difference was statistically significant(P<0.05). Conclusion Valsartan dispersible tablets combined with alprostadil injection has a definite clinical effect in the treatment of chronic glomerulonephritis, which can reduce adverse reactions, improve patients?? renal function, effectively control blood pressure, improve patients?? quality of life, and improve their psychological status. It is worthy of clinical application.

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